GM,WM,andCSFwere segmentedwiththe3DVIEWNIXsoftwaresystem(21)by analyzingbothprotondensity–andT2-weightedimages.The processbeganwithsegmentationoftheintracranialbrain(GM, WM,andCSF)byusingthetheoryoffuzzyconnectedness(22). Allsegmentedbrainvolumeimages